🤖 GLOBAL HEALTH OPTIMIZATION AGENT v3.0

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🧪 Experimental Design

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Trial Search

Current Search Criteria:

Intervention: Abemaciclib with ET

Found 17 matching trials

Endocrine Therapy With Abemaciclib or Chemotherapy as Initial Metastatic Treatment in ER+/HER2- Breast Cancer

PHASE3

AMBRE is a phase III study comparing two standard treatments as initial met...

Status

Active Not Recruiting

Location

Centre Hospitalier Lyon Sud

Start Date

2020-06-11

Trial ID

NCT04158362

Treatments Being Tested

Paclitaxel injection Capecitabine tablets Letrozole 2.5mg Anastrozole 1mg Fulvestrant Prefilled Syringe Abemaciclib

Functional Imaging in Prediction of Response to Abemaciclib for Advanced Hormone Receptor-Positive, HER2-Negative Breast Cancer

PHASE2

This phase II trial tests the accuracy of functional imaging (FFNP)-positro...

Status

Recruiting

Location

Siteman Cancer Center at Washington University

Start Date

2024-07-22

Trial ID

NCT06179303

Treatments Being Tested

Abemaciclib Anastrozole Biospecimen Collection Computed Tomography Diagnostic Imaging Testing Exemestane Fludeoxyglucose F-18 Fluorine F 18 Fluoro Furanyl Norprogesterone Fulvestrant Gonadotropin-releasing Hormone Analog Letrozole Positron Emission Tomography Tamoxifen Therapeutic Estradiol

A Vaccine (STEMVAC) With Standard Endocrine-Based Therapy or Chemotherapy for the Treatment of Metastatic Hormone Receptor Positive, HER2 Negative Breast Cancer

PHASE2

This phase II trial studies how well a vaccine, STEMVAC, works in combinati...

Status

Recruiting

Location

Fred Hutch/University of Washington Cancer Consortium

Start Date

2025-11-17

Trial ID

NCT07112053

Treatments Being Tested

CD105/Yb-1/SOX2/CDH3/MDM2-polyepitope Plasmid DNA Vaccine Capecitabine Computed Tomography Cyclin-Dependent Kinase 4 Inhibitor Cyclin-Dependent Kinase 6 Inhibitor F-18 16 Alpha-Fluoroestradiol Hormone Therapy Positron Emission Tomography Biopsy Procedure Biospecimen Collection Abemaciclib

A Non-interventional Study for Kisqali (Ribociclib) in Combination With an Aromatase Inhibitor for Adjuvant Treatment in Patients With HR+/HER2- Early Breast Cancer at High Risk of Recurrence

N/A

This non-interventional observational study evaluates the real-world effect...

Status

Recruiting

Location

Novartis Investigative Site

Start Date

2025-02-20

Trial ID

NCT06830720

Treatments Being Tested

ribociclib + AI ± LHRH abemaciclib + ET ± LHRH ET mono ± LHRH

A Study of Abemaciclib (LY2835219) Plus Hormone Therapy in Participants With Early Breast Cancer

PHASE3

The main purpose of this study is to measure how well abemaciclib works in ...

Status

Terminated

Location

Palo Verde Cancer Specialists

Start Date

2021-05-10

Trial ID

NCT04752332

Treatments Being Tested

Abemaciclib Standard Adjuvant ET Placebo

A PoC Study to Evaluate Treatments' Efficacy by Monitoring MRD Using ctDNA in HR-positive/HER2-negative EBC Population

PHASE2

This trial is a multicenter, open-label, non-comparative, phase II, biomark...

Status

Recruiting

Location

Complejo Hospitalario Universitario A Coruña (CHUAC)

Start Date

2024-04-01

Trial ID

NCT05708235

Treatments Being Tested

Giredestrant Abemaciclib Inavolisib Standard ET followed by change in treatment

First-in-Human Study of Tersolisib (STX-478) as Monotherapy and in Combination With Other Antineoplastic Agents in Participants With Advanced Solid Tumors

PHASE1

Study STX-478-101 (LY4064809) is a multipart, open-label, phase 1/2 study e...

Status

Recruiting

Location

Ellison Clinic at Saint John's

Start Date

2023-04-17

Trial ID

NCT05768139

Treatments Being Tested

STX-478 Fulvestrant Ribociclib Palbociclib Letrozole Anastrozole Exemestane Tamoxifen Abemaciclib Imlunestrant Metformin

A Randomised Trial Comparing Trastuzumab Deruxtecan to CDK4/6 Inhibitors in Non-luminal A, ER-positive/HER2-low Metastatic Breast Cancer

PHASE3

The objective of this trial, DBCG R25, will be to evaluate the effect of tr...

Status

Withdrawn

Location

Multiple Locations

Start Date

2026-01-01

Trial ID

NCT06585969

Treatments Being Tested

Trastuzumab deruxtecan (T-DXd)Ribociclib with ET Abemaciclib with ET

A Study of Abemaciclib (LY2835219) in Participants With Breast Cancer, Non-small Cell Lung Cancer, or Melanoma That Has Spread to the Brain

PHASE2

The main purpose of this study is to evaluate the safety and effectiveness ...

Status

Completed

Location

City of Hope National Medical Center

Start Date

2015-04-20

Trial ID

NCT02308020

Treatments Being Tested

Abemaciclib

A Study of Tersolisib (LY4064809/STX-478) With Other Anti-Cancer Treatments in Participants With Advanced Breast Cancer With a Genetic Change (PIK3CA)

PHASE3

The purpose of the study is to assess the efficacy and safety of the additi...

Status

Recruiting

Location

Alaska Oncology and Hematology

Start Date

2025-12-22

Trial ID

NCT07174336

Treatments Being Tested

LY4064809 Placebo Ribociclib Palbociclib Abemaciclib Anastrozole Letrozole Exemestane Fulvestrant

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